BLINCYTO® must be administered as a continuous intravenous infusion, delivered at a constant flow rate using an infusion pump. The infusion pump should be programmable, lockable, non-elastomeric, and have an alarm.1
In each treatment cycle, patients receive 28-day continuous BLINCYTO® infusion, followed by a 14-day treatment-free period. Patients may receive 2 cycles of induction treatment followed by 3 additional cycles of BLINCYTO® consolidation treatment (up to a total of 5 cycles).1
Fixed Dosing for Patients Weighing ≥ 45 kg
BSA-Based Dosing for Patients Weighing < 45 kg
Hospitalization is recommended for the first 9 days of the first cycle and the first 2 days of the second cycle.1
For all subsequent cycle starts and reinitiation (eg, if treatment is interrupted for 4 or more hours), supervision by a health care professional or hospitalization is recommended.1
IMPORTANT NOTE: Do not flush the BLINCYTO® infusion line or intravenous catheter, especially when changing infusion bags. Flushing when changing bags or at completion of infusion can result in excess dosage and complications thereof. When administering via a multi-lumen venous catheter, BLINCYTO® should be infused through a dedicated lumen.
It is very important that the instructions for preparation (including admixing) and administration provided in the full Prescribing Information are strictly followed to minimize medication errors (including underdose and overdose).1